Immune System Health

Quality probiotic supplements like Flora Infused tell you exactly which probiotic strains you’re getting. 2020, CD006634 (2020). Then whether it is a recurrent cold and flu, sniffles during the winter months, allergies, asthma or infections, we get them all and blame it on our weak immunity. Allow the kraut to ferment three days to three weeks, tasting along the way. Early studies of how probiotics affect immunity have provided scientists with encouraging results by regulating cytokines production.

Novak added that probiotics are unnecessary for people who eat healthily. They also decrease responsiveness of T and B lymphocytes and the number of T helper (Th) 1, Th2, and Th17 cytokines without inducing apoptosis. Lactobacillus bulgaricus is the ancient contribution of mankind to modern science and to the creation of the first healthy foods in the world. Your immune system needs support during your recovery and, with so many of your immune system cells residing in your gut, it only makes sense to begin there. One of these characterizations suggests that the host is able to tolerate the large amount of antigens present in the gut [27], owing to the coordinated cross talk between the gut microbiota and the immune system. How to boost your immune system: 12 tricks that work. With the help of probiotics, primary bile acids, namely, cholic acid and chenodeoxycholic acid, convert to deoxycholic acid and lithocholic acid, respectively [69, 70]. This refers to the number of bacteria available that can establish themselves in the gut.

  • H7 infections were demonstrated in vitro in MDCK-I and T84 epithelial cell monolayers [39].
  • In the T84 epithelial cells monolayer model, Lactobacillus casei DN-114001 stabilizes the ZO-1 distribution against the enteropatogenic Escherichia coli E2348/69 [55].
  • This is also seen in the elderly where a lack of probiotic friendly bacteria results in frequent infections.
  • Antibiotics can be helpful, but unfortunately they are not selective; they kill both harmful and helpful bacteria at the same time.
  • With a molecular weight greater than 30 kDa, the BLS was identified as probably belonging to class III bacteriocins, i.
  • Apart from these foods, there are new products that have been developed to increase or combine these useful components because of their benefits or desired physiological effects.

Then, local dendritic cells are able to sample antigens and present them to immune effector cells [21]. Of note, in a microarray-based comparative genome hybridization analyses, Eileen and collaborators identified two novel bacteriocins in L. There are studies revealing how probiotics actually regulate our immune system thus leading to an increase in immunity against diseases caused by a compromised (or abnormal) immune system.

They form an ecosystem like a “flower garden”, reported Haruji Sawada, director of the Yakult Central Institute, at the Yakult International Nutrition and Health Conference on May 17, 2020, in Tokyo. In addition, segmented filamentous bacteria can be presented to T cells by dendritic cells and contribute to the synthesis of Th17 cells in lamina propria of small intestine, thus playing a vital role in antibacterial immune response [47, 48]. These mechanisms can contribute to the inhibition and elimination of potential pathogens, improvement of intestinal microenvironment, strengthening the intestinal barrier, attenuation of inflammation, and enhancement of antigen-specific immune response [38, 39].

Then in 2020, researchers in New Zealand examined if probiotics boosted the immune response. Nowadays, the exact mechanism of interaction between probiotic microorganisms and host cells remains elusive. Incubation of L.

Mechanisms of Action

Can’t I just eat yogurt to get probiotics? Lancet 357, 1076–1079 (2020). Whether they’re catching the latest bug at daycare, putting everything they touch in their mouths, or forgetting to wash their hands, children need all the support they can get for a strong immune system. The MD Anderson study found that 42 percent of the patients studied were also taking probiotic supplements. Disturbed intestinal immune niche is a contributory cause for the digestive diseases such as inflammatory bowel disease (IBD), functional dyspepsia, gastroesophageal reflux disease, and nonalcoholic fatty liver disease. Similarly, if the immune system is already warmed up, it can better cope with pathogenic invaders. You’ll find a complete list of our product’s ingredients when you click on Ultimate Immune.

The best types of fermented foods include unsweetened yogurt, kefir (a fermented probiotic milk drink), sauerkraut, kimchi, and pickled vegetables. For instance, Escherichia coli and Lactobacillus rhamnosus can upregulate mucin expression in intestinal cells to enhance intestinal mucosal barrier. Th1-mediated autoimmune diseases.

  • But what happens when it fails – a germ successfully invades you and makes you sick.
  • In other words, probiotics are live, beneficial microorganisms similar to the “friendly” bacteria found naturally in our body’s digestive system.
  • Probiotics play a role in defining and maintaining the delicate balance between necessary and excessive defence mechanisms including innate and adaptive immune responses.
  • In addition, neutrophils from mice that were raised in a germ-free environment or on antibiotics were likewise diminished in their immune responses, but this effect was not permanent.

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The established probiotics that meet these criteria are generally lactic acid bacteria (LAB), most commonly Lactobacillus and Bifidobacterium species, but also Lactococcus, Streptococcus, and Enterococcus species and certain yeast strains. Prebiotics are not actually bacteria themselves but the food that bacteria “eat”. Select foods that have been refrigerated and say they have live cultures or have not been pasteurized since the heat of pasteurization kills the good bacteria. Downregulation of production of proinflammatory cytokines and other inflammatory mediators seems to constitute important mechanisms for the partial amelioration of colitis, seen with numerous LAB strains in various models. If you feed them, they will come! Subsequently they demonstrated that VSL#3 was inducing a significant over-expression of the MUC2 gene as well as a similar, although milder, effect for MUC1 and MUC3 genes in vitro [15].

This will help to re-establishing the healthy balance of microorganisms in your gut, and reassert the strength of your ‘good’ bacteria over the bad. Your immune system is a smart, strong network within your body that keeps you safe from dangers like bad bacteria, viruses, and parasites. Goldenberg adds. A richer, more fruitful quality of life is just ahead. In fact, the guts of those who took probiotics took much longer than those who did not to fully recover.

Probiotics offer a beneficial defense against the effects caused by this unwarranted inflammation. Intraepithelial αβT and γδT lymphocytes, NK cells, and NKT cells can also be gathered among intestinal epithelial cells. 54 Khazaie, K. Some of the most commonly studied strains promote T cells and the so-called Killer cells. Evolution of the human immune response: why infectious diseases affect us differently. There are some scientific studies to show that diets rich in probiotics reduce the risk of cancers by increasing the activity of immune ( Natural Killer) cells that detect and attack cancer cells in the body. The gut microbiota can also enhance host immunity through MyD88-independent mechanisms (MyD88 – Myeloid differentiation primary response gene 88). Before the start of the therapy, researchers also took fecal samples from each patient — profiling the bacterial makeup of their respective microbiomes.

A general benefit to taking probiotics to prevent illness.

The Microbiota and the Immune System

You can learn more about Health Trinity here. Therefore, probiotics can have many different effects on our immune system. Since intestinal macrophages, dendritic cells, and natural killer T cells express bile acids receptors such as GPBAR1 and FXR, intestinal bile acids can bind to these receptors and suppress NLRP3 mediated inflammatory response to maintain immune homeostasis [71, 72]. Equally valuable is their ability to help metabolize and break down body wastes. Unfortunately, pathogens and other germs aren’t easy to avoid. Always be sure that the products you are taking have been scientifically backed to ensure that they will be effective. Hopefully, these approaches will be more effective which can be applied in a personalized manner in the future. Youtube, iodine toxicity can occur when a horse is fed too much seaweed. USA 102, 10321–10326 (2020).

Similar data were also observed when EcN was administered to murine models for colitis suggesting that upregulation of the ZO-1 stabilizes the TJs and therefore improves the barrier function of the intestinal epithelium [74]. The probiotics in your gut are there to ensure that the bad bacteria do not take over. An increased expression of the ZO-1 and occludin genes was also observed for Lactobacillus plantarum strain WCFS1 [41] and Lactobacillus plantarum strain CGMCC No. Approximately 40 percent of iIELs are thymus-dependent αβ T cells and their phenotype is similar to peripheral T cells.

Lactobacillus Acidophilus (“L.acidophilus”)

But even if they are just passing through, they appear to be the ideal type of houseguest that leaves the place a bit better than they found it. Elinav said the findings “are in perfect agreement” with conclusions from his own research: The remains are Actinobacteria, Proteobacteria, Verrucomicrobia, and Fusobacteria [33, 34]. USA 105, 16731–16736 (2020).

2 Outside the volume of the Cherenkov detector

Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake. A major advantage of probiotic supplements is that you can select the strain of bacteria suited to your needs, as well as the potency. This function may decrease infections and immune-related reactions, thus supporting the health of the immune system. Th1 and Th17 effector T-cell subsets are polarized and produce inflammatory cytokines such as TNF-α, IFN-γ, and IL-17 [25]. 63 Pineda Mde, L. When you have a good balance of bacteria, you can efficiently convert these carbohydrates into valuable sources of nutrients and energy. Finally, specific strains of probiotic bacteria like L.

10, 66–78 (2020).

This also makes sense to safeguard us from the dreaded visit to the doctor or the long course of terrible tasting antibiotics. Those taking the probiotics who caught a cold[i]: Lactobacillus fermentum strain CS57 was recently isolated from vaginal swabs and shown to produce a bacteriocin-like substance (BLS), with a wide spectrum of antimicrobial activity [67].

This study found that consuming fermented milk, which is rich in probiotic bacteria, actually changes the brain’s emotional response to stimuli on a structural level. Beneficial effects of the lactobacilli on the body have been identified in the treatment or prevention of acute viral gastroenteritis, after antibiotic-associated diarrhea, certain pediatric allergic diseases, necrotizing enterocolitis, and inflammatory bowel disease such as Crohn’s disease and postoperative hernias. Therefore, the authors propose Lactobacillus plantarum G1 (and G3) as potential novel probiotics [82]. Immune system disorder, igE production by B cells during the late phase of allergic reactions causes a secondary immune response. 25 [25, 61, 77]. Thus, probiotics that enhance the generation of regulatory dendritic cells to induce Tregs, represent a potential therapeutic approach for inflammatory disorders [50, 54]. 20, 5–10 (2020). Although the functional analysis of the gene coding for this compounds was not yet completed, similar bacteriocin compounds were also identified in other bacteria strain: Science 334, 105–108 (2020).

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These tablets have been shown to deliver 60% or more of their bacteria past stomach acid. Dr miriam stoppard: fasting presses the body’s reset switch and gets rid of damaged cells. It doesn’t matter how many oranges you eat – if you can’t digest them properly then you won’t benefit from all that vitamin C. The influence of the microbiome is driven not only by the gross quantity of microbes present, but also the composition and diversity of the bacteria. Lactobacillus casei, Lactobacillus plantarum, Lactobacillus bulgaricus, and Lactobacillus acidophilus; three strains of Bifidobacteria and S. This modulating effect helps alleviate excessive inflammation in the gut, thereby boosting immune function.

Inflammatory diseases are often caused by microbial dysbiosis. What about kombucha? Science 331, 337–341 (2020). Many people who are lactose intolerant might think they have to miss out on probiotics because they are so commonly found in dairy products. In addition, you can look out for yogurts that have live cultures added to them. Chop or shred cabbage into fine ribbons (the finer the chop, the more juices that will be released). Seventy percent of the cells that make up our immune system are found in the digestive tract, explaining how probiotics support both digestion and the immune system. Specific probiotic bacterial strains have been demonstrated to regulate mucin expression therefore influencing the properties of the mucus layer and indirectly regulate the gut immune system.

SCFA also plays a crucial role in homing of T cells. Ways to boost your immune response and fight disease, pass the guac! 8, 587–596 (2020). These probiotics will typically deliver less than 4% of their bacteria to your gut. In addition, the gut plays a key role in the digestion of food and subsequent absorption of vitamins, minerals and other nutrients – including those that are vital for the immune system! Mucins are high molecular weight glycoproteins divided in two groups:

  • 55, 1441–1453 (2020).
  • Check the label on your current supplement to see whether it contains filler ingredients, inert substances, and artificial colors & sweeteners- then compare what you’re taking with Orenda Ultimate Immune to see why Orenda is better.
  • Chen-xing Zhang and Hui-yu Wang are co-first authors and contributed equally to the work.
  • Gut’s role in immune function The contributions of the gut microbiota to the development of the immune system have been extensively characterized.
  • The use of murine models demonstrated that the consumption of fermented milks can modulate the immune system and can maintain it in a state of surveillance, which could affront different pathologies such as cancer and intestinal inflammation on its part.

Tips & Benefits

The effects of probiotics are well-documented in relation to improving digestive health in a number of ways. In a bifactorial stress mouse model we studied the effect of probiotic supplementation on biochemical parameter in serum, the intestinal impairment of the villi induced by stress, the systemic immune response and the susceptibility to intestinal infections. Comparison of the immunomodulatory properties of three probiotic strains of lactobacilli using complex culture systems: Epithelial tissues in the intestines form a barrier against pathogenic microbes and other harmful substances present.

” There is truth to this as 70-80% of our entire immune system resides within the gut. Trp can be decomposed into various metabolites by microflora. After all, the microbial cocktails are available over the counter and have been shown to be helpful in the treatment of gastrointestinal illnesses for some people. He said he would not recommend probiotics as a first-line treatment for most inflammatory bowel diseases in most patients.

Microbiota vary too significantly from person to person, and immunotherapy responses might even vary depending on age, ethnicity, and gender, Daud said. These probiotics can help you maintain the right levels of bacteria in the digestive tract: (2 billion CFU.) Caballero-Franco and collaborators indeed administered a probiotic formula (VSL#3) to rat models and observed a 60% increase in the basal mucin luminal content [15].

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The first and best way to do this, is to take an extra close look at your diet. They’re actually a type of fiber that can’t be broken down in the gut. The effectiveness on the immune system exerted by probiotic consumption suggests the use of these bacteria as an alternative to minimize the damage induced during stress situation. Is commercial yogurt ok since it’s pasteurized?

Lymphocytes in the lamina propria usually congregate together to form intestinal follicle, which contains germinal centers populated by B cells and follicular dendritic cells, topped by immature dendritic cells, macrophages, CD4+T cells, and mature B cells [12, 13]. These molecules will recruit peripheral neutrophils and mast cells to intestinal subepithelial regions and accelerate activation and differentiation of local lymphocytes. Nevertheless, there is enough gathered information that microbiota in the gut could affect the immune response at both systemic and mucosal levels. Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin–p38 MAPK pathway. As much as 70-80% of immune cells are located in the gut, so the health of your gut can really impact on the health of your entire immune system. The product must also be handled correctly and refrigerated if needed, since heat will kill some probiotic organisms. Lifestart is also beneficial for pregnant women who want to boost their own immune systems, as well as those of their growing babies. 119, 184–191 (2020).

You probably need a minimum of 2 billion CFU to be effective and to consume them for at least two weeks before they kick in, says lead researcher Katherine Black, PhD, of the Department of Human Nutrition at the University of Otago, New Zealand. Try to avoid to many inflammatory foods like alcohol, dairy and red meat as well. Lactobacillus and Bifidobacteria are most commonly applied probiotics in clinical practice. Cortisol and the immune response, in fact, in AD, other than the main pathological hallmarks such as Amyloid-β plaques and neurofibrillary tangles, also the increased levels of pro-inflammatory cytokines and reduction of the anti-inflammatory system are a central feature of the disease [ 82 84 ]. However, a breakdown in the process of immune hemostasis will lead to gut pathology such as food allergy and inflammatory bowel disease [22, 23]. But this hypothesis is too simplistic, and the term has been abused and misinterpreted. Synbiotics are foods or dietary supplements that contain both probiotics and prebiotics.

1 Inside the volume of the Cherenkov detector

It’s much easier to start moving if a car is idling than if its engine is cold. The effect of may benefit children and adults with irritable bowel syndrome and adults with ulcerative colitis; studies with reference to probiotics? Pregnant women who were given a probiotic during the third trimester had better immunity and gave birth to babies with lesser allergies and eczema. The interaction between probiotics and host cells as well as intestinal flora is a key factor which influences the host health. Probiotics and immune health Hippocrates (460-370 EC) stated, “All diseases begin in the gut.

They do this by releasing enzymes and by-products that kill germs.
  • There are experimental and clinical data [18-24].
  • The intestinal surface is covered with a large number of finger-like projections called microvilli (also named brush border), whose primary function is the absorption of nutrients.
  • Allergy 39, 571–578 (2020).
  • In addition, bile acids also regulate chemokine CXCL16 expression on liver sinusoidal endothelial cells (LSECs) and the accumulation of CXCR6+ hepatic NKT cells, which exhibit activated phenotypes and inhibit liver tumor growth [73].
  • Skin issues, particularly those commonly seen in infants, are thought to be due to a delay in the development of immune function.

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Scientists have found that the way your immune systems determines your own cells from attackers, is by detecting the protein within the cell. The double-blind placebo-controlled study divided 272 healthy people into two groups. It may surprise you that the majority of the immune system - around 70-80% - is actually located in the gut. Homeostasis and inflammation in the intestine.

Serve your salad with a side of kraut, fermented beets or fermented chutney. Hpv treatments symptoms information help human papillomavirus, tiro serves as co-leader of the Population Science and Cancer Control Program. J Autoimmun 2020;29: It has been shown that Lactobacillus bulgaricus adheres best on the colonic mucosa, followed by a rapid reproduction in the body. What matters most is that the modulation of the immune system is one of the most reasonable mechanisms underlying the beneficial effects of probiotics on human health. Fermented fruits: The integrity of the GIT epithelium is partially guaranteed by multi-protein complexes defined as TJs (Fig. Influenza in people with normal and weakened immune systems, how do we know our immune system is ineffective or run down? )TJ’s function and biology have been extensively reviewed elsewhere (for details, refers to [75] and references within). But could these probiotics have more uses than improving digestion?

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Probiotics do work for some people, and some conditions: This has further resulted in elevated levels of TNF-α and inflammasome and reduced levels of IL-10, TGF-β, and IL-35 [43]. Safety results were not reported in 37 percent of the trials included in the evidence review, researchers found. Inflammation and the immune system are also closely tied, with inflammation acting as a signal to trigger an immune response.

Even as recently as 10-20 years ago, we did not understand the extent to which the gut microbiome can influence a person’s mood, regulate appetite, produce essential vitamins, regulate the immune system, and influence systemic inflammation.

The more varied the probiotic, the morediverse your immune system will become. Another way to nurture a healthy gut is to consume foods that contain beneficial bacteria. Dendritic cells in intestinal Peyer’s patch (PP) and mesenteric lymph nodes (MLN) express Aldh1a1 and Aldh1a2, respectively, and therefore produce RA locally. Daud noted that he did have one melanoma patient that he treated with pembrolizumab — an anti-PD-L1 immunotherapy — who actually seemed to benefit from probiotic use. If your gut is not healthy, your immune system cannot be either. 21, e386–e393 (2020). Science 2020;303:

  • Press them down with force so that air pockets are expelled and the juice rises over the vegetables.
  • Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways.
  • No matter what time of year it is, you’ll be exposed to viruses and other bacteria in the air, in food, and on everyday items.
  • As the health of the immune system is directly impacted from the health of the gut wall, one of the best ways we can assist our gut is to support the health of beneficial bacteria.
  • Today, nutrition science faces new challenges far beyond the concept of food insufficiency.
  • Probiotics have been found to help promote the production of bacteriocins (bacteria-killing agents) and short chain fatty acids, as well as lowering gut pH and competing for binding sites on the cells of the gut lining.
  • If you’re struggling with recurring colds & bouts of the flu or are looking for a way to start building a stronger immune system, give Orenda Ultimate Immune a try and see a difference in the way you feel in just one week.

The Limitations of Conventional Probiotics

This will result in the sharp reduction of the expenses for healthcare and in the optimization of physical and mental health of the population. He added that the main mechanisms that account for the anti-inflammatory activities include suppressing inflammation-causing cytokines such as: 2 billion CFU) and Bifidobacterium longum (0. Probiotics have little effect in rheumatoid arthritis, but they can help with dermatitis and other allergic reactions. 14 of the 30 taking the probiotic never developed a respiratory infection. Inflammation is at the root of most of the debilitating chronic neurological conditions we face today, so probiotic interventions that balance the gut microbiome and reduce inflammation have the potential to drastically improve brain health. Probiotics also promote mineral absorption from the foods you eat.

Bifidobacterial surface-exopolysaccharide facilitates commensal–host interaction through immune modulation and pathogen protection. By limiting the interaction and penetration of bacteria, a healthy mucus layer plays an important role in preventing inflammatory and infectious diseases. Combine kefir with frozen berries. Petrova have isolated Lactobacillus bulgaricus and other fermented milk probiotic microorganisms from spring water in Bulgaria [62, 63]. If your immune system has been chronically weakened by a gut imbalance like Candida, you may find that you’re picking up every infection that comes your way. If you’re looking to protect your health this cold and flu season, you may want to add probiotics to your diet.


Many factors can disturb our intestinal balance of bacteria: As a cofactor of sphingosine-1-phosphate (S1P) lyase, vitamin B6 is involved in the degradation of S1P. Marijuana: more than just the high, if you have heart disease, this could raise your risk of heart attack. The level for tumour necrosis factor (TNF)-alpha, another important circulating cytokine also dropped. You can pretty much get probiotics in two ways: Here, the Treg cells secrete molecules such as IL-10 and TGF-β which exert a suppressive action on immune cells. He wrote, “Let food be your medicine and medicine – your food. “My two cents would be, this study reminds us that there’s no question that probiotics have a powerful impact on the immune system,” Cohen said.

7, 503–514 (2020). Dendritic cells produce IL-4 and TGF-β and induce CD4+ T differentiation into Th2 subset, with upregulated levels of IL-4 and GATA3 transcription factor. In this case, the stability of the epithelial barrier structure was guaranteed by ZO-1 and claudin-1, both important TJ proteins.

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Strategies to manipulate the microbiota during infancy have been shown to prevent development of allergic and atopic diseases later in adult life [38-40]. “But this is an isolated, n=1 case — so I don’t know how much weight this carries,” Daud said. The accepted notion is that probiotics stimulate the immune lymphoid tissue found in the gut. Such foods are consumed as part of the standard diet [66]. Essentially, your body loses its protective army of good bacteria, whose job it is to fight off any pathogens that enter your body.


Many of us do not sleep long enough, work too many hours, deal with chronic stress, and prioritize our family’s health over our own. 4, 368–374 (2020). This is because as you mature from a child to an adult, your body has a chance to be exposed to more threats. Accumulating evidence over the last decade indicates that the immune system and microbiota interaction should be finely balanced and any perturbations of this interaction would result in microbiota and immune dysbiosis, leading to inflammatory disorders The rapid surge in the emerging new-age disorders such as inflammatory bowel disease (IBD), rheumatoid arthritis, cardiovascular disease, and metabolic syndrome has driven investigators to explore their etiology in multiple directions such as genetics, diet, and environmental factors, as well as immune system/microbiota interactions. In addition to this creation of lactic acid, Bacillus coagulans also creates beneficial compounds known as bacteriocins, which are known to reduce bad bacteria. Studies show probiotics can benefit the communications within your gut-brain axis. Among the different human mucin genes, MUC2 and MUC3 are the ones predominant in the colon [47].

Belizna CC, Richard V , T huillez C, Levesque H, Shoenfeld Y. How to boost the immune system against coronavirus, , multiple sclerosis), and susceptibility to infection (including viral respiratory infections). American companies test possible probiotic effects of known spore-carrying microorganisms from the Bacillus family. Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: 44 Dotterud, C. Tolerance will be evaluated by means of the record of gastrointestinal symptoms and the record of aspect and frequency of faeces.

Functionally, the BLS produced by L. The authors declare that they have no conflicts of interest. The best way to do it is through probiotics. Hahn BH, Grossman J , Chen W , McMahon M. Peritoneal and spleen macrophages activity, the immune response to ovalbumin immunization, the protection against Salmonella infection during the stress process in mice receiving probiotic, were also determined. What your immune system really needs is support from a regular dose of probiotics. Another powerful link between the gut and overall health lies in the development of obesity. Probiotics such as Lactobacillus and Bifidobacteria can help maintain the balance as probiotics can positively affect one’s immune system and may be effective against diseases caused by abnormalities in the immune system.